This article covers a real-world subject which should not be taken as part of the Holby universe.
- Rosie Marcel as Jac Naylor
- Alex Walkinshaw as Adrian "Fletch" Fletcher
- Darcey Burke as Emma Naylor-Maconie
- Ramin Karimloo as Kian Madani
- Hugh Quarshie as Ric Griffin
- Catherine Russell as Serena Campbell
- Jaye Jacobs as Donna Jackson
- Marcus Griffiths as Xavier "Zav" Duval
- Jo Martin as Max McGerry
- Belinda Owusu as Nicky McKendrick
- Carmen Munroe as Alison Nelsson
- James Quinn as Jeremy Purnell
- Tom Xander as Ricus De Souza
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