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Guy Self is a neurosurgeon and the former chief executive officer of Holby City Hospital.

Behind the scenes

John Michie initially portrayed Guy in Holby City from November 2013 to November 2016. He reprised his role as Guy for an additional nine episodes in 2017 and one episode in 2018. In March 2020, it was revealed in Holby City's spring trailer that Michie would make a third return to the show.