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Series 12 of Holby City commenced on 20 October 2009 and finished on 12 October 2010; it comprised 55 episodes.
Cast[]
Main characters[]
- Hugh Quarshie as Ric Griffin
- Amanda Mealing as Connie Beauchamp
- Paul Bradley as Elliot Hope
- Hari Dhillon as Michael Spence
- Duncan Pow as Linden Cullen
- Rosie Marcel as Jac Naylor
- Luke Roberts as Joseph Byrne
- Bob Barrett as Sacha Levy
- Edward MacLiam as Greg Douglas
- James Anderson as Oliver Valentine
- Emma Catherwood as Penny Valentine
- Robert Powell as Mark Williams
- Tina Hobley as Chrissie Williams
- Patsy Kensit as Faye Byrne
- Rebecca Grant as Daisha Anderson
- Jaye Jacobs as Donna Jackson
- Olga Fedori as Frieda Petrenko
- Phoebe Thomas as Maria Kendall
- La Charné Jolly as Elizabeth Tait
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| Series 11 | Series 13 |