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Series 15 of Holby City commenced on 16 October 2012 and finished on 8 October 2013; it comprised 52 episodes.
Main Characters
- Guy Henry as Henrik Hanssen
- Catherine Russell as Serena Campbell
- Hugh Quarshie as Ric Griffin
- Paul Bradley as Elliot Hope
- Rosie Marcel as Jac Naylor
- Hari Dhillon as Michael Spence
- Aden Gillett as Edward Campbell
- Bob Barrett as Sacha Levy
- Jimmy Akingbola as Antoine Malick
- Joseph Millson as Luc Hemingway
- Chizzy Akudolu as Mo Effanga
- James Anderson as Oliver Valentine
- Jules Knight as Harry Tressler
- Jing Lusi as Tara Lo
- Rob Ostlere as Arthur Digby
- Ty Glaser as Gemma Wilde
- Camilla Arfwedson as Zosia March
- Tina Hobley as Chrissie Williams
- Sarah-Jane Potts as Eddi McKee
- Michael Thomson as Jonny Maconie
- Niamh McGrady as Mary-Claire Carter
- Lauren Drummond as Chantelle Lane
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