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Series 17 of Holby City commenced on 14 October 2014 and finished on 6 October 2015; it comprised 52 episodes.
Main Characters
- John Michie as Guy Self
- Guy Henry as Henrik Hanssen (from episode 29)
- Catherine Russell as Serena Campbell
- Hugh Quarshie as Ric Griffin
- Rosie Marcel as Jac Naylor
- Paul Bradley as Elliot Hope (until episode 50)
- Don Gilet as Jesse Law (from episode 3)
- Bob Barrett as Sacha Levy
- Chizzy Akudolu as Mo Effanga
- Joe McFadden as Raffaello Di Lucca
- Jules Knight as Harry Tressler (until episode 27)
- James Anderson as Oliver Valentine (from episode 11)
- Rob Ostlere as Arthur Digby
- David Ames as Dominic Copeland
- Camilla Arfwedson as Zosia March
- Eleanor Fanyinka as Morven Shreve (from episode 38)
- Louise Delamere as Colette Sheward (until episode 4)
- Michael Thomson as Jonny Maconie (until episode 37)
- Alex Walkinshaw as Adrian "Fletch" Fletcher
- Niamh McGrady as Mary-Claire Carter (until episode 27)
- Kaye Wragg as Essie Harrison (from episode 26)
- Niamh Walsh as Cara Martinez (from episode 36)
- Petra Letang as Adele Effanga
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| Series 16 | Series 18 |
