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Series 21 of Holby City commenced on 2 January 2019 and finished on 31 December 2019; it comprised 53 episodes.
Cast
Main characters
- Guy Henry as Henrik Hanssen (until episode 33)
- Catherine Russell as Serena Campbell
- Rosie Marcel as Jac Naylor
- Bob Barrett as Sacha Levy
- Dawn Steele as Ange Godard (from episode 2)
- Hugh Quarshie as Ric Griffin
- Ramin Karimloo as Kian Madani (from episode 17)
- Jo Martin as Max McGerry (from episode 42)
- Olga Fedori as Frieda Petrenko (until episode 13)
- Marcus Griffiths as Xavier "Zav" Duval
- David Ames as Dominic Copeland
- Amy Lennox as Chloe Godard (from episode 5)
- Belinda Owusu as Nicky McKendrick
- Nic Jackman as Cameron Dunn (from episode 1)
- Alex Walkinshaw as Adrian "Fletch" Fletcher
- Jaye Jacobs as Donna Jackson
- Kaye Wragg as Essie Di Lucca
- Lee Mead as Ben "Lofty" Chiltern (until episode 51)
Recurring characters
- Julia Deakin as Carole Copeland
- Darcey Burke as Emma Naylor-Maconie
- Jules Robertson as Jason Haynes
- Stanley Rabbetts as Theo Fletcher (until episode 12)
- Dana Smit as Sara Johanssen (until episode 33)
- Poppy Jhakra as Amira Zafar (until episode 12)
- Hamish Clark as Ken Davies (until episode 22)
- Zoe Croft as Greta Allinson (until episode 1)
- Marko Leht as Roman Makarenko (until episode 4)
- Sirine Saba as Patricia Ghraoui (until episode 25)
- Debbie Chazen as Fleur Fanshawe (until episode 47)
- Angela Lonsdale as "Scary" Sue Buchanan (until episode 27)
- Suzette Llewellyn as Nanette Duval (until episode 26)
- Francesca Barrett as Beka Levy (until episode 51)
- Briana Shann as Mia Barron (until episode 15)
- Emma Curtis as Holly Cartwright (episodes 5 - 11)
- Philip Whitchurch as Jim Mullins (episodes 5 - 9)
- Marianne Oldham as Ruth Cooper (episodes 6 - 11)
- Christopher Harper as Michael Cartwright (episodes 7 - 11)
- Camilla Arfwedson as Zosia March (episodes 8 - 16)
- Naomi Katiyo as Darla Johnstone (episodes 10 - 41)
- Jack Ryder as Evan Crowhurst (episodes 12 - 44)
- Daisy Wood-Davis as Phoebe Palmer (episodes 14 - 51)
- Marc Elliott as Isaac Mayfield (episodes 20 - 24)
- Harry Weston as Oskar Johansson (episodes 23 - 33)
- Verity Marshall as Helen Pidge (episodes 28 - 48)
- Sally Scott as Sophie Taylor (episodes 29 - 40)
- Heather Peace as Alex Dawson (from episode 30)
- Emily Bowker as Stacey Clarkson (from episode 32)
- Sophie Harkness as Frankie Rendell (episodes 34 - 42)
- Rosalind Halstead as Beatrice "Bea" Kaminski (episodes 41 - 52)
- Paul Bradley as Elliot Hope (episodes 45 - 50)
- Charlie Condou as Ben Sherwood (from episode 52)
Guest characters
- Denis Lawson as Tom Campbell-Gore (episodes 1 - 3)
- Sara Stewart as Arianne Cornell (episode 1)
- Siubhan Harrison as Mica Khan (episode 1)
- Tim Preston as Duncan McKenzie (episode 2)
- Brian Pettifer as Laurie Stocks (episode 2)
- Lorraine Chase as Cherie Grimes (episodes 2 & 48)
- Lorenzo Rodriguez as Damien McKenzie (episode 2)
- Sharon D Clarke as Lola Williams (episode 3)
- Kenya Sterling as Harriet Wakefield (episode 3)
- John Arthur as Edward Turnbull (episode 3)
- Emma Dewhurst as Mel Simons (episode 3)
- Tony Pritchard as Nigel Dylan (episode 4)
- Rose Shalloo as Ellen MacCoubrie (episode 4)
- Trevor Michael Georges as Gareth Gannon (episode 5)
- Sophie Wise as Tavia Milner (episode 5)
- Rebecca Atkinson as Denise Mullins (episode 5)
- Hunter David as Lee Kierney (episode 6)
- Felicite de Jeu as Françoise Durand (episode 6)
- Sarah Munro as Busker (episode 6)
- Amerjit Deu as Mr Burman-Roy (episode 7)
- Tom Durant Pritchard as Andy Gray (episode 7)
- Tamzin Griffin as Vanessa McQueen (episodes 8 & 9)
- Amanda Mealing as Connie Beauchamp (episode 10)
- Jason Durr as David Hide (episode 10)
- Michael Stevenson as Iain Dean (episode 10)
- Rebecca Ryan as Gem Dean (episode 10)
- Neet Mohan as Rashid Masum (episode 10)
- Shaheen Jafargholi as Marty Kirkby (episode 10)
- Jaye Griffiths as Elle Gardner (episode 10)
- Tony Marshall as Noel Garcia (episode 10)
- Maddy Hill as Ruby Spark (episode 10)
- Richard Pepple as Kofi Johnstone (episode 11)
- Marek Wroblewski as Ivan Demko (episode 13)
- Joanne Dion as Leona Dempsey (episodes 13 & 14)
- Idris Debrand as Keir Dempsey (episode 13)
- Benaya Julius as Luis Groves (episodes 14 & 15)
- Paul Clayton as Roger Ffolkes (episode 15)
- Phil Rowson as Archie Nelson (episode 15)
- Laura Doddington as Abbey Ealy (episode 16)
- Madison Clare as Roberta Martinez (episode 16)
- Andrew Langtree as Mark Hancock (episode 17)
- Seraphina Beh as Maz Emanuel (episode 17)
- Llewella Gideon as Pat Dryden (episode 17)
- Roger Evans as Douglas Dryden (episode 17)
- Ulrika Krishnamurti as Farhima Noorani (episode 18)
- Kathryn Howden as Marlene Garrison (episode 18)
- Waleed Akhtar as Jamal Noorani (episode 18)
- Barney White as Rory Faulkner (episode 19)
- Sarah Douglas as Victoria Parker (episode 19)
- Claire Cordier as Maxine Billton (episode 20)
- Jack Gouldbourne as Kris Williams (episode 20)
- Brian Murphy as Buster Kitchener (episode 20)
- Geoffrey Leesley as Jon Mayfield (episodes 21 - 23)
- Stefan Bednarczyk as Lawrence Conway (episode 22)
- Paul Copley as Roger Keelan (episode 24)
- Frances Jeater as June Keelan (episode 24)
- Ricky Fearon as Marlon Duval (episode 25)
- Hugh Sachs as "Galvo" Daniel Kenny (episode 26)
- Ian Saynor as Tony Brown (episode 26)
- Jessica Claire as Susie Brown (episode 26)
- Tok Stephen as Mason Marles (episode 27)
- Roxanne Palmer as Karen Winter (episode 28)
- Claire Hackett as Beattie Jude (episode 28)
- Sam Frenchum as Jerry McKee (episode 29)
- Jane Maud as Barbara Lovett (episode 29)
- Natalie Mendoza as Sunny Lin (episode 30)
- Ashley Margolis as Brody Lyttle (episode 30)
- Nicola Duffett as Delia Hamel (episode 31)
- Leo Woodall as Jake Reader (episode 31)
- Chandeep Uppal as Nessa Dalal (episode 31)
- David Roper as Keith Murdoch (episode 32)
- Anthony May as George Hopley (episode 33)
- Julia Foster as Freda Hopley (episode 33)
- Sarah Woodward as Lilly Gellar (episode 33)
- Miroslav Kokenov as Boiko Toshkov (episode 34)
- Jason Callender as Emile Endersby (episode 34)
- Olwen May as Kristy Maltby (episode 35)
- Yasmin Taheri as PC Hammett (episode 35)
- Jane Crawshaw as Abigail Robins (episode 36)
- Adam Kotz as Jonathan Robins (episode 36)
- Patsy Kensit as Faye Byrne (episode 36)
- Luke Roberts as Joseph Byrne (episode 36)
- Aewia Huillet as Mrs Tan (episode 37)
- Hayley Lam as Mi-Hi Tan (episode 37)
- Michelle Lam as Mi-Cha Tan (episode 37)
- Kate Maravan as Leigh Gledhill (episode 38)
- Orla Hill as May Gledhill (episode 38)
- David Partridge as Carl Daniels (episode 40)
- Eve Macklin as Sheena Weston (episode 40)
- Jordan Adene as Peter Woodward (episode 41)
- Calum Lill as Conor Henson (episode 41)
- Daniel Adegboyega as Michael Woodward (episode 41)
- Joel Robinson as Callum Loveitt (episode 42)
- Camilla Watson as Casey Fresle (episode 42)
- Daon Broni as Leo Griffin (episode 43)
- Patricia Potter as Diane Lloyd (episode 43)
- Leah Mondesir-Simmonds as Erika Johnstone (episode 43)
- Ben Fox as Ged Lees (episode 44)
- Marlene Sidaway as Josie O'Grady (episode 45)
- Eva Fontaine as Simone Milton (episode 45)
- Steven O'Neill as Neil Pointon (episode 45)
- Tanya Burr as Joanne Pearsons (episode 46)
- Vicky Entwistle as Sandra Jackson (episode 46)
- Michael Tully as Frederick Houghton (episode 49)
- Sarah Ball as Annalise Houghton (episode 49)
- Kathryn Pogson as Madeleine Gentry (episode 50)
- Connie Hyde as Jackie Marley (episode 50)
- Joanne Mitchell as Josette Dorsey (episode 50)
- Jamie Davis as Max Walker (episode 51)
- Amanda Henderson as Robyn Miller (episode 51)
- Robert Mountford as Rajan Sinha (episode 52)
- Jamie Chapman as Alan Green (episode 52)
- Marie Lawrence as Penelope Wright (episode 53)
- Laurel Waghorn as Jay Richards (episode 53)
- Ron Donachie as Richard MacDonagh (episode 53)
Episodes
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