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Series 21 of Holby City commenced on 2 January 2019 and finished on 31 December 2019; it comprised 53 episodes.

Cast

Main characters

Recurring characters

  • Julia Deakin as Carole Copeland
  • Darcey Burke as Emma Naylor-Maconie
  • Jules Robertson as Jason Haynes
  • Stanley Rabbetts as Theo Fletcher (until episode 12)
  • Dana Smit as Sara Johanssen (until episode 33)
  • Poppy Jhakra as Amira Zafar (until episode 12)
  • Hamish Clark as Ken Davies (until episode 22)
  • Zoe Croft as Greta Allinson (until episode 1)
  • Marko Leht as Roman Makarenko (until episode 4)
  • Sirine Saba as Patricia Ghraoui (until episode 25)
  • Debbie Chazen as Fleur Fanshawe (until episode 47)
  • Angela Lonsdale as "Scary" Sue Buchanan (until episode 27)
  • Suzette Llewellyn as Nanette Duval (until episode 26)
  • Francesca Barrett as Beka Levy (until episode 51)
  • Briana Shann as Mia Barron (until episode 15)
  • Emma Curtis as Holly Cartwright (episodes 5 - 11)
  • Philip Whitchurch as Jim Mullins (episodes 5 - 9)
  • Marianne Oldham as Ruth Cooper (episodes 6 - 11)
  • Christopher Harper as Michael Cartwright (episodes 7 - 11)
  • Camilla Arfwedson as Zosia March (episodes 8 - 16)
  • Naomi Katiyo as Darla Johnstone (episodes 10 - 41)
  • Jack Ryder as Evan Crowhurst (episodes 12 - 44)
  • Daisy Wood-Davis as Phoebe Palmer (episodes 14 - 51)
  • Marc Elliott as Isaac Mayfield (episodes 20 - 24)
  • Harry Weston as Oskar Johansson (episodes 23 - 33)
  • Verity Marshall as Helen Pidge (episodes 28 - 48)
  • Sally Scott as Sophie Taylor (episodes 29 - 40)
  • Heather Peace as Alex Dawson (from episode 30)
  • Emily Bowker as Stacey Clarkson (from episode 32)
  • Sophie Harkness as Frankie Rendell (episodes 34 - 42)
  • Rosalind Halstead as Beatrice "Bea" Kaminski (episodes 41 - 52)
  • Paul Bradley as Elliot Hope (episodes 45 - 50)
  • Charlie Condou as Ben Sherwood (from episode 52)

Guest characters

  • Denis Lawson as Tom Campbell-Gore (episodes 1 - 3)
  • Sara Stewart as Arianne Cornell (episode 1)
  • Siubhan Harrison as Mica Khan (episode 1)
  • Tim Preston as Duncan McKenzie (episode 2)
  • Brian Pettifer as Laurie Stocks (episode 2)
  • Lorraine Chase as Cherie Grimes (episodes 2 & 48)
  • Lorenzo Rodriguez as Damien McKenzie (episode 2)
  • Sharon D Clarke as Lola Williams (episode 3)
  • Kenya Sterling as Harriet Wakefield (episode 3)
  • John Arthur as Edward Turnbull (episode 3)
  • Emma Dewhurst as Mel Simons (episode 3)
  • Tony Pritchard as Nigel Dylan (episode 4)
  • Rose Shalloo as Ellen MacCoubrie (episode 4)
  • Trevor Michael Georges as Gareth Gannon (episode 5)
  • Sophie Wise as Tavia Milner (episode 5)
  • Rebecca Atkinson as Denise Mullins (episode 5)
  • Hunter David as Lee Kierney (episode 6)
  • Felicite de Jeu as Françoise Durand (episode 6)
  • Sarah Munro as Busker (episode 6)
  • Amerjit Deu as Mr Burman-Roy (episode 7)
  • Tom Durant Pritchard as Andy Gray (episode 7)
  • Tamzin Griffin as Vanessa McQueen (episodes 8 & 9)
  • Amanda Mealing as Connie Beauchamp (episode 10)
  • Jason Durr as David Hide (episode 10)
  • Michael Stevenson as Iain Dean (episode 10)
  • Rebecca Ryan as Gem Dean (episode 10)
  • Neet Mohan as Rashid Masum (episode 10)
  • Shaheen Jafargholi as Marty Kirkby (episode 10)
  • Jaye Griffiths as Elle Gardner (episode 10)
  • Tony Marshall as Noel Garcia (episode 10)
  • Maddy Hill as Ruby Spark (episode 10)
  • Richard Pepple as Kofi Johnstone (episode 11)
  • Marek Wroblewski as Ivan Demko (episode 13)
  • Joanne Dion as Leona Dempsey (episodes 13 & 14)
  • Idris Debrand as Keir Dempsey (episode 13)
  • Benaya Julius as Luis Groves (episodes 14 & 15)
  • Paul Clayton as Roger Ffolkes (episode 15)
  • Phil Rowson as Archie Nelson (episode 15)
  • Laura Doddington as Abbey Ealy (episode 16)
  • Madison Clare as Roberta Martinez (episode 16)
  • Andrew Langtree as Mark Hancock (episode 17)
  • Seraphina Beh as Maz Emanuel (episode 17)
  • Llewella Gideon as Pat Dryden (episode 17)
  • Roger Evans as Douglas Dryden (episode 17)
  • Ulrika Krishnamurti as Farhima Noorani (episode 18)
  • Kathryn Howden as Marlene Garrison (episode 18)
  • Waleed Akhtar as Jamal Noorani (episode 18)
  • Barney White as Rory Faulkner (episode 19)
  • Sarah Douglas as Victoria Parker (episode 19)
  • Claire Cordier as Maxine Billton (episode 20)
  • Jack Gouldbourne as Kris Williams (episode 20)
  • Brian Murphy as Buster Kitchener (episode 20)
  • Geoffrey Leesley as Jon Mayfield (episodes 21 - 23)
  • Stefan Bednarczyk as Lawrence Conway (episode 22)
  • Paul Copley as Roger Keelan (episode 24)
  • Frances Jeater as June Keelan (episode 24)
  • Ricky Fearon as Marlon Duval (episode 25)
  • Hugh Sachs as "Galvo" Daniel Kenny (episode 26)
  • Ian Saynor as Tony Brown (episode 26)
  • Jessica Claire as Susie Brown (episode 26)
  • Tok Stephen as Mason Marles (episode 27)
  • Roxanne Palmer as Karen Winter (episode 28)
  • Claire Hackett as Beattie Jude (episode 28)
  • Sam Frenchum as Jerry McKee (episode 29)
  • Jane Maud as Barbara Lovett (episode 29)
  • Natalie Mendoza as Sunny Lin (episode 30)
  • Ashley Margolis as Brody Lyttle (episode 30)
  • Nicola Duffett as Delia Hamel (episode 31)
  • Leo Woodall as Jake Reader (episode 31)
  • Chandeep Uppal as Nessa Dalal (episode 31)
  • David Roper as Keith Murdoch (episode 32)
  • Anthony May as George Hopley (episode 33)
  • Julia Foster as Freda Hopley (episode 33)
  • Sarah Woodward as Lilly Gellar (episode 33)
  • Miroslav Kokenov as Boiko Toshkov (episode 34)
  • Jason Callender as Emile Endersby (episode 34)
  • Olwen May as Kristy Maltby (episode 35)
  • Yasmin Taheri as PC Hammett (episode 35)
  • Jane Crawshaw as Abigail Robins (episode 36)
  • Adam Kotz as Jonathan Robins (episode 36)
  • Patsy Kensit as Faye Byrne (episode 36)
  • Luke Roberts as Joseph Byrne (episode 36)
  • Aewia Huillet as Mrs Tan (episode 37)
  • Hayley Lam as Mi-Hi Tan (episode 37)
  • Michelle Lam as Mi-Cha Tan (episode 37)
  • Kate Maravan as Leigh Gledhill (episode 38)
  • Orla Hill as May Gledhill (episode 38)
  • David Partridge as Carl Daniels (episode 40)
  • Eve Macklin as Sheena Weston (episode 40)
  • Jordan Adene as Peter Woodward (episode 41)
  • Calum Lill as Conor Henson (episode 41)
  • Daniel Adegboyega as Michael Woodward (episode 41)
  • Joel Robinson as Callum Loveitt (episode 42)
  • Camilla Watson as Casey Fresle (episode 42)
  • Daon Broni as Leo Griffin (episode 43)
  • Patricia Potter as Diane Lloyd (episode 43)
  • Leah Mondesir-Simmonds as Erika Johnstone (episode 43)
  • Ben Fox as Ged Lees (episode 44)
  • Marlene Sidaway as Josie O'Grady (episode 45)
  • Eva Fontaine as Simone Milton (episode 45)
  • Steven O'Neill as Neil Pointon (episode 45)
  • Tanya Burr as Joanne Pearsons (episode 46)
  • Vicky Entwistle as Sandra Jackson (episode 46)
  • Michael Tully as Frederick Houghton (episode 49)
  • Sarah Ball as Annalise Houghton (episode 49)
  • Kathryn Pogson as Madeleine Gentry (episode 50)
  • Connie Hyde as Jackie Marley (episode 50)
  • Joanne Mitchell as Josette Dorsey (episode 50)
  • Jamie Davis as Max Walker (episode 51)
  • Amanda Henderson as Robyn Miller (episode 51)
  • Robert Mountford as Rajan Sinha (episode 52)
  • Jamie Chapman as Alan Green (episode 52)
  • Marie Lawrence as Penelope Wright (episode 53)
  • Laurel Waghorn as Jay Richards (episode 53)
  • Ron Donachie as Richard MacDonagh (episode 53)

Episodes

Episode No. Series No. Title Director(s) Writer(s) Original airdate
956 1 "Everything Old Is New Again" Tracey Rooney Katie Douglas 2 January 2019
957 2 "China Crisis" Ian Barnes Joe Ainsworth 8 January 2019
958 3 "The Burden of Proof" Ian Barnes Gerard Sampaio 15 January 2019
959 4 "A Daring Adventure or Nothing at All" Daikin Marsh Isla Gray 22 January 2019
960 5 "Mad as Hell" Daikin Marsh Martin Jameson 29 January 2019
961 6 "Force Majeure" Ruth Carney Elliot Hope and Johanne McAndrew 5 February 2019
962 7 "Good Side" Ruth Carney Ed Sellek 12 February 2019
963 8 "Never Say Never" Waris Islam Nick Fisher and Patrick Holmes 19 February 2019
964 9 "Guts" Waris Islam Martin Jameson and Patrick Holmes 26 February 2019
965 10 "Powerless" Steve Brett Michelle Lipton 5 March 2019
966 11 "A Simple Lie - Part One" Julie Edwards Patrick Homes 19 March 2019
967 12 "A Simple Lie - Part Two" Nimer Rashed Patrick Homes 20 March 2019
968 13 "Running" Stuart Jones Tony Higgins 26 March 2019
969 14 "Ask No Questions" Stuart Jones Michelle Lipton and Kathrine Smith 2 April 2019
970 15 "The Family Way" Emma Lindley Becky Prestwich 9 April 2019
971 16 "North and South" David Innes Edwards Joe Ainsworth 16 April 2019
972 17 "Pleased To Meet You" Jamie Annett Ed Sellek 23 April 2019
973 18 "Vinegar and Honey" Jamie Annett Ed Sellek 30 April 2019
974 19 "Ex Marks the Spot" Michael Lacey Joe Ainsworth 7 May 2019
975 20 "The Wrong Horse" Michael Lacey Nick Fisher 14 May 2019
976 21 "Unredeemed" Karl Neilson Andy Bayliss 21 May 2019
977 22 "Bloodline" Karl Neilson Ed Sellek and Patrick Cash 28 May 2019
978 23 "In the Right Place" Jermain Julien Ed Sellek 4 June 2019
979 24 "Over My Dead Body" Jermain Julien Joe Ainsworth 11 June 2019
980 25 "Pigeon" Paulette Randall Andy Bayliss 20 June 2019
981 26 "Kiss Kiss" Paulette Randall Katie Douglas, Andy Bayliss and Johanne McAndrew 25 June 2019
982 27 "Flying Solo" Sean Glynn Martin Jameson 9 July 2019
983 28 "Reckless" Sean Glynn Nick Fisher 10 July 2019
984 29 "Honeymoon" Tracey Rooney Gerard Sampaio 16 July 2019
985 30 "Don't Leave Me" Tracey Rooney Alisa Macauley 23 July 2019
986 31 "Things My Mother Told Me" Waris Islam Martin Jameson 30 July 2019
987 32 "When Worlds Collide" Waris Islam Andrew Rattenbury 6 August 2019
988 33 "Work-Life Balance" Julie Edwards Simon Norman 13 August 2019
989 34 "Where Does It Hurt?" Julie Edwards Ed Sellek 20 August 2019
990 35 "Babysitters and Bystanders" David Innes Edwards Ed Sellek 27 August 2019
991 36 "The Perfect Storm" David Innes Edwards Joe Ainsworth and Sam Wheats 3 September 2019
992 37 "Gods and Monsters" Michael Lacey Alex Straker 10 September 2019
993 38 "Circle of Life" Michael Lacey Alison Hume 17 September 2019
994 39 "Retreat" Steve Brett Andy Bayliss 24 September 2019
995 40 "Divine Justice" Jamie Annett Andy Bayliss 1 October 2019
996 41 "This Be the Verse" Jamie Annett George Holden Stroud 8 October 2019
997 42 "Hope Is a Powerful Drug" Griff Rowland Simon Norman 15 October 2019
998 43 "Promise" Griff Rowland Patrick Homes 22 October 2019
999 44 "Hubble Bubble" Tracey Rooney Joe Ainsworth 29 October 2019
1000 45 "Remember, Remember" Tracey Rooney Joe Ainsworth 5 November 2019
1001 46 "Sandra's Choice" Thomas Hescott Damian Mullen 12 November 2019
1002 47 "We Are All the Stars" Thomas Hescott Katie Douglas 19 November 2019
1003 48 "Blurring the Lines" Daikin Marsh Andrew Rattenbury 26 November 2019
1004 49 "Bell Jar" Daikin Marsh Martin Jameson 3 December 2019
1005 50 "Kintsugi" David Tucker Martin Jameson 10 December 2019
1006 51 "Lemons" David Tucker Ed Sellek 17 December 2019
1007 52 "Be True, Be Brave, Be Kind" Steve Brett Ed Sellek 19 December 2019
1008 53 "Mothers and Their Daughters" Steve Brett Patrick Homes 31 December 2019
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