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- George Irving as Anton Meyer (until episode 46)
- Siobhan Redmond as Janice Taylor (until episode 44)
- Dominic Jephcott as Alistair Taylor (episodes 1 - 46)
- Hugh Quarshie as Ric Griffin (from episode 1)
- Mark Moraghan as Owen Davis (from episode 3)
- Denis Lawson as Tom Campbell-Gore (from episode 45)
- Thusitha Jayasundera as Tash Bandara (until episode 37)
- Jeremy Sheffield as Alex Adams
- Ian Aspinall as Mubbs Hussein (from episode 8)
- Patricia Potter as Diane Lloyd (from episode 39)
- Rocky Marshall as Ed Keating (from episode 45)
- Colette Brown as Sam Kennedy (until episode 45)
- Jan Pearson as Kath Shaughnessy
- Peter de Jersey as Steve Waring
- Tina Hobley as Chrissie Williams
- Laura Sadler as Sandy Harper
- Anna Mountford as Keri McGrath (until episode 41)
- Adrian Lewis Morgan as Liam Evans (until episode 35)
- Luisa Bradshaw-White as Lisa Fox (from episode 13)
- Verona Joseph as Jess Griffin (from episode 15)
- David Paisley as Ben Saunders (from episode 17)
- Jeremy Edwards as Danny Shaughnessy
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