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- Paul McGann as John Gaskell
- Hermione Gulliford as Roxanna MacMillan
- Catherine Russell as Serena Campbell
- Salma Hoque as Meena Chowdhury
- Kaye Wragg as Essie Di Lucca
- Jaye Jacobs as Donna Jackson
- Rosie Marcel as Jac Naylor
- Alex Walkinshaw as Adrian "Fletch" Fletcher
- Olga Fedori as Frieda Petrenko
- Marcus Griffiths as Xavier "Zav" Duval
- Belinda Owusu as Nicky McKendrick
- James Anderson as Oliver Valentine
- Lee Mead as Ben "Lofty" Chiltern
- David Ames as Dominic Copeland
- Bob Barrett as Sacha Levy
- Hugh Quarshie as Ric Griffin
- Guy Henry as Henrik Hanssen
- Jules Robertson as Jason Haynes
- Shannon Murray as Fiona Fawcett
- Kika Markham as Lesley Fawcett
- Hamish Clark as Ken Davies
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