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St James' General Hospital, often shortened to St James', is a general hospital in the Chipping Marsh area of Holby. It is one of two main hospitals in the city, the other being Holby City Hospital.

Behind the scenes

St James' Hospital is frequently mentioned throughout Casualty and Holby City but has only been featured twice in the former. It was depicted on-screen in the 2009 episode "Sunset Syndrome" and a 2021 episode. For the 2021 appearance, the hospital's exterior was shot outside the Gloworks building which is located opposite Roath Lock in Cardiff — the studio that houses the emergency department interior and exterior sets.