"The Point of No Return" is the 391st episode of Casualty and the 31st episode of the 17th series. It was preceded by "An Act of God" and followed by "Stuck in the Middle With You". The episode was directed by Declan O'Dwyer and written by David Joss Buckley.
The episode features the departure of Lisa "Duffy" Duffin, portrayed by Cathy Shipton. However, Shipton reprised her role for guest appearances in 2006, 2015 and 2016, and returned permanently as the character in August 2016 at the start of series 31. Russell Boulter also made his departure as Ryan Johnson, but made a guest appearance in two episodes in December 2016.