In early 2017, Dylan contacted Zsa Zsa to discuss operating on Glen Thomas who wanted to extend his life to be able to see his daughter. Zsa Zsa sympathised with his plight and flew to the UK to operate on him for free. She talked him and Dylan through the procedure, but she warned Glen that there was a 50% chance of the operation causing catastrophic brain damage. After a coin toss, Glen agreed to the procedure. (CAS: Episode 1061)
In April, Zsa Zsa operated on Glen. Unfortunately, there was a bleed and Glen began to seize. Zsa Zsa managed to remove a significant portion of the tumour but Glen was left in a coma. In June, Zsa Zsa bid Dylan farewell and returned to the United States. (CAS: Episode 1061)
In October, David Hide called Zsa Zsa to help Dylan after his breakup with Ciara Cassidy and the loss of their child. Upon arriving in Holby, she took David and Jeffers to Dylan's houseboat and broke in. She soon received a call from Brian Carroll, Dylan's father, who told her that his son needed all the help he could get and gave her their location. They soon arrived at a pub, but they soon realised that they were at the wrong one. David soon noticed a British passport falling out of Jeffers' pocket, and he admonished Zsa Zsa for trying to take Dylan away with her to the US. They soon found Dylan trying to treat Brian after he hit his head on a table, and he begged her to save his father. She reluctantly agreed and drilled a makeshift burr hole to evacuate a clot. After much persuasion from Zsa Zsa, Dylan successfully removed the clot. Once they arrived at the ED, Connie demanded to see Zsa Zsa and Dylan in her office, and she admonished her for her recklessness. Outside, Dylan declined her offer of accompanying her to the US, and thanked her for saving Brian. They shared a farewell hug, and David escorted her and Jeffers to the airport. (CAS: Episode 1101)
In February 2020, Dylan asked Zsa Zsa to review the case files of Lev Malinovsky and Faith Cadogan's child Luka who had a brain tumour situated close to his brain stem; she agreed, stating that she "loved a challenge". (CAS: Episode 1163) She flew over from the US to perform the surgery personally with Jeffers. When she arrived in Holby, she was thanked by Robyn for her role in extending Glen's life. After this, she was greeted by David, where she asked why Dylan was going above and beyond for Faith. She performed the operation on Luca, but after removing theh initial tumour, found more cancerous material deeper in the brainstem which she could not remove. This forced her to end the operation. She had to tell Faith and Lev the results, for which Lev angrily shouted at her that sh was supposed to fix his child. Faith apologised for this, but Zsa Zsa understood his anger. With nothing more she could do, her and Jeffers were seen off by David and Dylan, where she asked David to keep an eye on him, and maybe find him a "nice little porter" like he had found Rose. (CAS: Episode 1164)
Behind the scenes
Sharon Gless made her first appearance as Zsa Zsa Harper-Jenkinson in November 2017. Her casting was announced in July 2017. In June 2018, it was announced that Gless would reprise her role as Zsa Zsa in late 2018. Her second episode aired on 13 October 2018. In February 2020, Casualty announced Gless would reprise her role as Zsa Zsa after much speculation. Her third episode aired on 22 February 2020.